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Late clinical features

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Clinical features of late syphilis do not usually occur until after 2 years of age. These take the form of stigmata relating to early damage to developing structures:

  • facial abnormalities including frontal bosses, saddle nose, protruding mandible, Hutchinson's teeth, facial gumma
  • sabre tibia - tibial periostitis
  • interstitial keratitis
  • eighth nerve deafness
  • periostitis and Clutton's joints
  • juvenile neurosyphilis
  • paroxysmal cold haemoglobulinuria

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