Distribution of drugs change as children age, with differing total body water, fat, ECF and ICF levels occurring with growth.
Plasma protein binding is decreased in neonates.
Kernicterus can be caused by displacement of bilirubin from albumin by sulphonamides and other drugs.
The blood brain barrier has been thought to be important in neonatal response to centrally active drugs; however it does in fact function normally even in extreme prematurity.
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