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Management

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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  • mefloquine half-life is approximately 21 days - therefore elimination from the body is extremely slow
  • mefloquine has no specific antidote
  • mefloquine is non-dialysable
  • there is a suggestion that oral activated charcoal may enhance elimination of mefloquine - this however has been incompletely studied
  • often milder symptoms resolve spontaneously - therefore they require neither specific therapy or change of prophylactic drug
  • if stopping mefloquine is indicated then mefloquine should be replaced with an alternative malaria chemoprophylaxis if the patient remains at risk of malaria transmission
  • clinicians should seek expert advice if in doubt regarding management
  • seizures secondary to mefloquine treatment should be treated with standard anti-convulsant therapy
  • psychosis secondary to mefloquine often requires supervision by a psychiatrist

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