This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Release stimulation

Authoring team

Histamine is usually released by degranulation of the storing cell. This is triggered by a rise in intracellular calcium. Mechanisms which produce this rise include:

  • complement components C3a and C5a binding to receptors on the cell surface
  • binding of IgE to cell surface in association with antigen
  • histamine-releasing factors from various leukocytes e.g. neutrophils
  • platelet activation e.g. contact with collagen, antigen-antibody complexes
  • physical agents e.g. cold or trauma
  • the cytokine interleukin-1

Release is less likely if cyclic AMP concentration is elevated. Beta-adrenoceptor agonists may modulate histamine-producing cells in this way.

Once released, the effects of histamine are reduced by:

  • diffusion away from the site
  • histaminase enzymes
  • acetylation

Related pages

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.