Raised ALT and use of oral hypoglycaemic medication
- hepatic impairment is a contraindication to many different medications. Of note in diabetes, is the use of glitazones in the case of hepatic impairment associated with non-alcoholic fatty liver disease
- the first glitazone, thioglitazone, was withdrawn from use after deaths occurred secondary to hepatic failure. However now there is evidence that glitazones are an effective treatment in non-alcoholic fatty liver disease
- the use of glitazone therapy in patients with abnormal liver function tests should only be used on specialist advice (1)
Reference:
- Personal Communication (February 9th 2006). Aresh Anwar, Consultant Diabetologist, University Hospitals Coventry and Warwickshire.
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