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Pharmacokinetic variation

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Pharmacokinetic variations in inducing drug side effects include:

  • pharmacogenetic variation - genetic abnormalities
  • hepatic disease - liver has a large capacity for metabolism which is hard to diminish with damage, but shunting is important
  • renal disease - probably the most important - retention of drug or toxic product
  • cardiac disease
  • thyroid disease - hyperthyroidism may cause resistance

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