Tissue injury or necrosis
- acute myocardial infarction - the rise in CRP appears within 24-48 hrs. The level begins to fall by the third day and becomes negative after 1-2 weeks. The rise of CRP correlates with peak CK-MB levels but CRP occurs 1-3 days later. If the CRP remains high then this indicates tissue damage in the heart or elsewhere. CRP is not raised in angina, if there is no tissue damage
- infarction of other tissues
- rejection of kidney or marrow transplant
- malignancy, especially lung, colon, breast
- following surgery - usually begins to rise within 4-6 hrs to peak at 48-72 hrs. The failure to fall indicates possible infection
- burns
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