Frequency of creatinine/eGFR testing

Kidney function should be measured at least annually in the risk groups below:

Previously diagnosed CKD, including

• polycystic kidney disease
• reflux nephropathy
• biopsy-proven chronic glomerulonephritis
• persistent proteinuria
• urologically unexplained persistent haematuria

Conditions associated with a high risk of obstructive nephropathy, including

• known or suspected bladder outflow obstruction
• neurogenic bladder caused by spina bifida or spinal cord injury (N.B. calculated GFR may overestimate true GFR in these patients because of decreased muscle mass)
• urinary diversion surgery
• urinary stone disease due to primary hyperoxaluria, cystinuria, Dent?s disease, infections (with struvite stones), anatomical abnormalities, or a stone episode rate of > 1/y Conditions known to be associated with a high risk of silent development of CKD, including
• hypertension
• diabetes mellitus
• heart failure
• atherosclerotic coronary, cerebral, or peripheral vascular disease

Conditions requiring long-term treatment with potentially nephrotoxic drugs, including

• ACEIs and ARBs
• NSAIDs
• lithium carbonate
• mesalazine and other 5-aminosalicylic acid drugs
• calcineurin inhibitors (Cyclosporin, Tacrolimus)

Multisystem diseases that may involve the kidney, including systemic lupus erythematosus (SLE), vasculitis, myeloma, rheumatoid arthritis

A first degree relative with stage 5 CKD

Minimum frequency of measurement of kidney function according to estimated GFR (2) :

How frequently do you need to measure eGFR?

Reference:

• (1) The Renal Association (May 2006).UK CKD Guidelines.
• (2) NICE (September 2008). Chronic Kidney Disease - Early identification and management of chronic kidney disease in adults in primary and secondary care