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Side effects of azathioprine

Authoring team

The side effects of azathioprine include:

  • marrow suppression, with a reversible neutropenia in 20% of patients
  • infection
  • nausea
  • vomiting
  • diarrhoea
  • mucosal ulcers
  • hepatotoxicity
  • acute pancreatitis is a rare complication

Long-term immunosuppressive treatment with azathioprine in transplant patients is associated with an increased risk of cancers, notably non-Hodgkin's lymphoma, squamous cell skin cancer and hepatoma.

Reference:

  1. Jack KL, Koopman WJ, Hulley D, Nicolle MW. A Review of Azathioprine-Associated Hepatotoxicity and Myelosuppression in Myasthenia Gravis. J Clin Neuromuscul Dis. 2016 Sep;18(1):12-20.

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