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Clinical adverse events to sulphasalazine

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

  • Rash

Often non-specific erythematous dry & itchy. Stop drug if severe, consider using 1% hydrocortisone and/or antihistamines. Consider other causes. If mild re-introduce when settled.

  • Mouth ulcers/Stomatitis

Stop if severe, reduce dose if mild/moderate. Consider carbenoxalone or difflam mouth washes. Consider other causes.

  • Fever/flu-like illness

Stop drug. Unusual hypersensitivity reaction, do not re-introduce.

  • Nausea

Reduce dose, take with food. Try anti-emetic. Stop if unacceptable.

  • Urine discolouration

Reassure

  • Discolouration of soft contact lenses

Reassure

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