Clinical adverse events to sulphasalazine
- Rash
Often non-specific erythematous dry & itchy. Stop drug if severe, consider using 1% hydrocortisone and/or antihistamines. Consider other causes. If mild re-introduce when settled.
- Mouth ulcers/Stomatitis
Stop if severe, reduce dose if mild/moderate. Consider carbenoxalone or difflam mouth washes. Consider other causes.
- Fever/flu-like illness
Stop drug. Unusual hypersensitivity reaction, do not re-introduce.
- Nausea
Reduce dose, take with food. Try anti-emetic. Stop if unacceptable.
- Urine discolouration
Reassure
- Discolouration of soft contact lenses
Reassure
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