This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in


Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The cause of PSC is uncertain. The most common association is with ulcerative colitis which is found in up to 75% of patients. However, only 3-4% of patients with UC develop PSC.

Other conditions associated with PSC include:

  • Crohn's disease
  • retroperitoneal fibrosis
  • sarcoidosis
  • Riedel's thyroiditis

PSC is frequently associated with HLA-B8 and HLA-DR3.

The cellular immune system appears to play a part in primary sclerosing cholangitis. There is a decrease in the total number of circulating T cells, wheras the number of T cells in the portal tracts is increased. The ratio of CD4 to CD8 lymphocytes in the circulation is increased, as are the number and percentage of B cells. It is unknown whether these immunologic abnormalities are primary events or are due to the underlying disease.

Related pages

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.