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Dosage of methotrexate

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Consult expert advice. Specialist knowledge is required if managing the initiation and monitoring of patients on methotrexate.

  • start at 5mg or 10 mg oral or IM WEEKLY
  • folic acid 5 mg oral weekly, 3 days after methotrexate reduces adverse reactions
  • if inadequate response dose may be increased upto 20 mg weekly
  • total duration of treatment as long as clinically indicated

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