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Dosage of methotrexate

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Consult expert advice. Specialist knowledge is required if managing the initiation and monitoring of patients on methotrexate.

  • start at 5mg or 10 mg oral or IM WEEKLY
  • folic acid 5 mg oral weekly, 3 days after methotrexate reduces adverse reactions
  • if inadequate response dose may be increased upto 20 mg weekly
  • total duration of treatment as long as clinically indicated

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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