Meconium ileus is very frequently associated with cystic fibrosis.
The secretory disorder in cystic fibrosis results in loss intestinal mucus and blockage of pancreatic ducts with loss of tryptic digestion. As a result sticky, inspissated meconium blocks the lower ileum of the fetus. Meconium peritonitis may occur if perforation of the bowel may occurs during intra-uterine life.
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