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Galactose metabolism

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Plasma galactose, after traversing the cell membrane, may enter glycolsis by the following set of reactions:

  • galactokinase catalyzes the conversion of galactose to galactose-1-phosphate
  • galactose-1-phosphate uridyl transferse catalyzes the conversion of galactose-1-phosphate to uridyl diphosphate (UDP) galactose
  • UDP galactose-4-epimerase catalyzes the conversion of UDP galactose to glucose-1-phosphate
  • phosphoglucomutase catalyzes the conversion of glucose-1-phosphate to glucose-6-phosphate
  • glucose-6-phosphate can enter the glycolytic pathway

At times of low plasma galactose, the reversal of pathway flux can form galactose from glucose.

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