You can view 5 more pages before signing in

Physicochemical pathology

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

There have been some recent advances in the theory of pathogenesis:

calmodulin, a molecule that regulates skeletal contractile proteins after binding with calcium, is increased dramatically in those with progressive curves relative to those with relatively stable scoliosis. Platelet assays of calmodulin could be used to advantage by predicting those who are likely to fare worse and require earlier treatment.
there seems to be a disordered arrangement of microfibrillar elastic fibres in the ligamentum flavum of those requiring surgery for adolescent idiopathic scoliosis. The fibrils were also at a relatively lower density and there was a structural disruption in the glycoprotein fibrillin.

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.