Premature infants, infants exposed to perinatal asphyxia and breast fed babies (by up to a factor of 15) are most at risk of developing haemorrhagic disease of the newborn.
The newborn infant has virtually no hepatic stores of vitamin K and this enzyme is present in only low concentrations in human milk.
Delay in the establishment of lactation during the first week after birth may be a further risk factor.
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