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Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

  • early HDN; onset: 0-24h; common bleeding sites - intracranial, thoracic, abdominal, cephalohaematoma; aetiology - maternal drugs (warfarin, anti-convulsants)

  • classic HDN; onset: 1-7d; common bleeding sites - GIT,skin,nasal,circumcision; aetiology - idiopathic maternal drugs

  • late HDN; onset: 2-12wk; common bleeding sites - intracranial,skin,GIT - intracranial haemorrhage accounts for 50% of bleeding episodes at presentation; aetiology - idiopathic, presenting feature of other disease (CF, biliary atresia, alpha-1 antitrypsin def.); often some degree of cholestasis present


  • 1) Shearer, MJ (1995). Vitamin K. The Lancet 345, 229-34.

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