dexfenfluramine was previously used as an adjunct to dietary treatment for severe obesity. It is the dextrorotatory stereo isomer of fenfluramine, inhibiting the re-uptake and stimulates the release of 5-HT in the hypothalamus which is involved in appetite and feeding behaviour
primary pulmonary hypertension and heart valve disorders are recognised to be associated with the use of anorectic agents
dexfenfluramine and fenfluramine were withdrawn in October 1997 because of the evidence associated with development of valvular disorders and pulmonary hypertension
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