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Side effects

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

  • pain, swelling or redness at the injection site are common and may occur more frequently following subsequent doses
  • a small, painless nodule may form at the injection site; this usually disappears and is of no consequence
    • incidence of local reactions is lower with tetanus vaccines combined with acellular pertussis vaccines than with whole-cell pertussis vaccines, and similar to that after diphtheria (DT) vaccine

  • fever, convulsions, high-pitched screaming, and episodes of pallor, cyanosis and limpness occur with equal frequency after both DTaP and DT vaccines
  • confirmed anaphylaxis occurs extremely rarely
  • other allergic conditions may occur more commonly and are not contraindications to further immunisation (1)

  • Hib/Men C conjugate vaccine
    • mild side effects such as irritability, loss of appetite, pain, swelling, redness at the site of the injection and slighty raised temperature commonly occur
    • less commonly, crying, diarrhoea, vomiting, atopic dermatitis, malaise and fever over 39.5°C have been reported

Check The Green Book for uptodate details.

Check the Summary of Product Characteristics before prescribing/administering a Hib-containing vaccine.


  1. Immunisation Against Infectious Disease - "The Green Book".Chapter 16 Haemophilis influenzae type B (Hib) (April 2019)

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