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Contraindications to testosterone therapy

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Contraindications to testosterone therapy

The main contraindications to testosterone therapy (T therapy) are:1

  • Prostate cancer (locally advanced or metastatic)
  • Male breast cancer
  • An active desire to father children
  • Haematocrit >54%
  • Severe chronic heart failure (NYHA class IV)

An unevaluated prostate nodule or induration, or raised prostate specific antigen (PSA), should be fully investigated prior to starting T therapy.

Untreated sleep apnoea and severe LUTS have previously been considered contraindications to T Therapy, but more recent evidence suggests this may no longer be the case.2 These conditions should however, be fully investigated and optimally manged before starting treatment with testosterone.

References

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