The myometrium is relatively insensitive to oxytocin until late in pregnancy.
Physiological concentrations of oxytocin result in uterine contractions which are both strong and rhythmical.
Large doses may result in prolonged contraction, resulting in acute foetal hypoxia and even foetal death.
There is a risk of uterine rupture when contractions are augmented with oxytocin; this is especially significant in the presence of a caesarian scar.
Syntocinon is given by intravenous infusion.
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