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Hormonal factors

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Glucogenesis is one response to a diminution of plasma glucose levels. The hormone changes in response to low plasma glucose include:

  • increase in glucagon:
    • increases cAMP in hepatocytes which indirectly decreases the activity of 6-phosphofructokinase and pyruvate kinase
    • reduces the tendency for glycolysis to act in the opposite direction to gluconeogenesis
  • decrease in insulin: change acts to increase cAMP, so acting in tandem with glucagon
  • increase in glucocorticoids: permissive effect on other hormones

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