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Premature adrenarche

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Precocious puberty requires differentiation from the benign forms of puberty (1). These include:

  • Premature Thelarche:
  • it is the premature unilateral or bilateral development of the breast tissue in girls between the age of 12 to 24 months
  • there are no other associated pubertal changes. Bone age, growth velocity, and biochemical testing are normal
  • it is usually a diagnosis of exclusion. Frequent clinical follow up to monitor growth, and pubertal progression is required
  • Premature Adrenarche:
  • the early production of adrenal androgens characterizes this benign condition. It presents with pubic or axillary hair, body odor, or acne before the age of 8 years
  • there is no breast development in females and no testicular enlargement in males. Bone age is usually not advanced
  • it is essential to rule out exposure to androgen sources such as creams or gels, adrenal tumors, and late-onset CAH
  • Premature Menarche:
  • isolated premature menarche is the onset of vaginal bleeding in girls less than 7 years of age
  • they may present with either a single episode or few cycles (less than 3) of bleeding and have normal progression to puberty
  • recent studies have suggested no effect on adult height
  • sexual abuse, vaginal foreign body, and infections of the vulva and vagina need to be ruled out.


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