This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Aetiology of precocious puberty - summary of central and peripheral causes

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Precocious puberty is commonly defined as puberty that starts before age 8 in girls and 9 in boys (1)

The aetiology of precocious puberty can be considered in terms of:

  • as a result from early commencement of pulsatile secretion of gonadotrophin releasing hormone (GnRH) (gonadotrophin dependent precocious puberty or GDPP)
    • also known as "true" precocious puberty or central precocious puberty(CPP) (2) (i.e. all the phases of puberty occur - but just occur at an earlier stage than "normal" puberty) include
      • idiopathic GDPP (1,2,3,4)
        • this is commonest cause of precocious puberty
        • may be a family history of precocious puberty
      • CNS related causes of GDPP
        • tumours involving the hypothalamus (eg, hamartoma or glioma)
          • the most common brain lesion causing CPP is hypothalamic hamartoma (5)
        • malformations of hypothalamus
        • germinomas
          • a type of germ cell tumor that is most often found in the brain. Typically, germ cells migrate to the reproductive organs (female ovaries or male testes) during fetal development. However, if these germ cells don't migrate to the correct location, they can become trapped in the brain and multiply in areas where they should not
        • other space occupying lesions
        • congenital brain disorder
        • acquired injury or infection
      • Genetic syndromes - neurofibromatosis type 1 and Sturge-Weber and tuberous sclerosis have characteristic manifestations and are associated with GDPP

  • those related to increased sex steroid production, independent of GnRH (gonadotrophin independent precocious puberty or GIPP)

peripheral precocious pubertyprecocious pseudopuberty


Related pages

Create an account to add page annotations

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.


Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.