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Zona fasiculata and zona reticularis biosynthesis

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The zona fasiculata and reticularis have the enzyme 17-alpha-hydroxylase, which 17-hydroxylates pregnenolone and progesterone.

These 17-hydroxy steroid can then be metabolised as follows:

  • to 11-deoxycortisol, catalysed by 21 beta-hydroxylase
  • to cortisol, by 11 beta-hydroxylase

Alternatively a further reaction, catalysed by 17,20 lyase can convert the 17-hydroxysteroid to the sex hormone precursors.


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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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