This is the most common variant of MEN-II and is characterised by:
Medullary thyroid tumours are present in over 90% of cases. They are usually an early sign in MEN-IIA and commonly, are very slow growing. Mortality and morbidity may be reduced significantly by screening for serum calcitonin in combination with pentagastrin stimulation.
Phaeochromocytomas are present in about 50% of cases and are a major cause of death. They should be excluded or treated in any patient with MEN-IIA.
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