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Falsely low TSH and biotin

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

TSH may be falsely low in patients who take supplemental biotin, as biotin can interfere with some immunoassay platforms (1)

  • enquire about biotin use at the time of testing in patients with convincing signs or symptoms of hypothyroidism and a normal TSH, and ask patients to stop biotin supplements for several days before thyroid function testing

NICE note:

  • ask adults, children and young people with suspected thyroid dysfunction about their biotin intake because a high consumption of biotin from dietary supplements may lead to falsely high or low test results.

Reference:

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