effects of anabolic androgenic steroids (AAS) include:
anecdotal reports have linked AAS to myocardial infarction and sudden death
these cases have generally occurred in young men (using high doses of multiple androgens) without any previous cardiac history and normal coronary arteries on autopsy. A common autopsy finding are the hypercontracted, deeply eosinophilic cardiac myocytes with disruption of myofibrillar structure
use of AAS has also been associated with septal and left ventricular hypertrophy and cardiac arrhythmias
both systolic and diastolic dysfunction that was directly related to the dose and duration of AAS use
use of AAS, not unexpectedly, has been associated with polycythemia and adverse changes in clotting factors
one of the most commonly seen undesirable effects of androgens, particularly nonaromatizable androgens, is a significant decrease in high-density lipoprotein cholesterol
nonaromatizable androgens like stanozolol can decrease plasma high-density lipoprotein by more than 30%
decline is significantly less with use of aromatizable androgens such as testosterone
AAS also increase hepatic lipase activity, thereby contributing to dyslipidemia. All these pathways by which AAS influence cardiovascular risk make cardiovascular disease a serious consequence of AAS
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