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PUVA and minimisation of skin cancer risk

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NICE suggests guidance how to minimise skin cancer risk with PUVA:

  • do not use PUVA in people with psoriasis of any type and a genetic predisposition to skin cancer for example, xeroderma pigmentosum or familial melanoma

  • do not use PUVA when other appropriate treatments are available in:
    • people with a personal history of skin cancer or
    • people who have already received 150 PUVA treatments or
    • children

  • use PUVA with caution or consider other treatment options in:
    • people at risk of skin cancer (melanoma and non-melanoma type)
    • people with lighter skin types, such as skin types I or II on the Fitzpatrick scale12
    • people who are likely to require ciclosporin or long-term methotrexate
    • young people

  • offer lifetime skin cancer surveillance to people treated with PUVA who have:
    • had more than 150 PUVA treatments or
    • developed skin cancer

Reference:

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