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Clinical adverse events on penicillamine

Authoring team

  • Rash

Often non-specific erythematous dry & itchy. Stop drug if severe. Stop drug if bullous reaction occurs. Consider using 1% hydrocortisone and/or antihistamines. Consider other causes. If mild re-introduce when settled.

  • Mouth ulcers/Stomatitis

Stop if severe, reduce dose if mild/moderate. Consider carbenoxalone or difflam mouth washes. Consider other causes, check white cell count

  • Loss of taste

Common early in treatment. Usually reappears with time or when drug stoppped.

  • Metallic taste

Common early in treatment. Usually reappears with time or when drug stoppped. Stop if unacceptable.

  • Nausea

Reduce dose and take with food. Stop if unacceptable.

  • Lupus syndrome

Rare and difficult to diagnose. Stop drug and seek advice.

  • Dyspnoea/Bronchiolitis

Stop drug and seek advice

  • Myaesthenic symptoms

Stop drug and seek advice


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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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