Nodular melanoma

Nodular melanoma is the most rapidly growing and aggressive variant of malignant melanoma.

• characterized by the absence of a radial growth phase
• seen on the trunk and limbs of patients in their fifth or sixth decade of life
• males are commonly affected than females (1)
• typically, it arises on apparently normal skin, has relatively little melanin and a rich blood supply
• patients have a symmetrical, raised, firm, often uniformly coloured and frequently non-pigmented nodule which continue to enlarge and become more raised (2)
• ulceration is common, giving a poorer prognosis.

Reference:

• (1) Markovic SN et al. Malignant melanoma in the 21st century, part 1: epidemiology, risk factors, screening, prevention, and diagnosis. Mayo Clin Proc. 2007;82(3):364-80
• (2) Cancer Council Australia/Australian Cancer Network/Ministry of Health, New Zealand (2008). Clinical Practice Guidelines for the Management of Melanoma In Australia and New Zealand