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Kaposi's sarcoma-associated herpesvirus

Authoring team

Human Herpesvirus 8 is closely related to Epstein-Barr Virus (HHV-4)

  • HHV-8 is an opportunist and generally does not cause disease in healthy hosts. Immunosuppression or AIDS is usually required before disease is manifested

  • HHV-8 infects CD19+ B cells and endothelial- derived spindle cells of Kaposi's sarcoma lesions

  • in addition to its role in Kaposi's sarcoma, it is known to cause a primary lymphoma (primar-effusion lymphoma) and a B cell lymphoproliferative disorder (a specific subtype of Castleman's disease)

  • a case of bone marrow failure with plasmacytosis has been reported resulting from HHV-8 infection following renal transplantation

Reference:

  • 1) P.S. Moore (2000). Editorial NEJM, 343(19), 1411-1413

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