Epidermolysis bullosa simplex
Epidermolysis bullosa simplex is caused by a suprabasal split in the epidermis. It is regarded to be the most common form of Epidermolysis bullosa (1).
This form tends to present at the onset of mobility, with blisters occuring on the knees and elbows and progressing to the hands and lower legs. There is no scarring.
Inheritance of this form is autosomal dominant and mutations in the proteins keratin 5 (K5) and keratin 14 (K14) has been recognized as the causative factor (2).
There are three major subtypes of Epidermolysis bullosa simplex:
Reference:
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