primary irritant | allergic contact | |
Prior exposure | none required | sensitisation needed to substance |
Spread | little extension from contact site | may spread to sites not in direct contact |
Association | atopy predisposes | prolonged use of topical medicaments may predispose |
Susceptibility | everyone | only certain people |
Course | Rapid onset within 4-12 hours. Lesions develop on first exposure | Onset usually after 24 hours. No lesions on first exposure. |
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