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Aetiology

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Behcet’s syndrome is a systemic venulitis.

The aetiology of Behcet’s disease is not fully understood, however, a combination of genetic and environmental factors may play a role (1):

  • there is a strong HLA association with HLA-B51; this genetic marker is found in around 60% of BD patients (1)
  • Herpes simplex virus-1 (HSV-1) and Streptococcus have been postulated as possible environmental triggers of BD (2)

Reference:

  1. Nair JR, Moots RJ. Behcet’s disease. Clin Med (Lond). 2017 Feb;17(1):71-77. Doi: 10.7861/clinmedicine.17-1-71. PMID: 28148585; PMCID: PMC6297594.
  2. Greco A, De Virgilio A, Ralli M, Ciofalo A, Mancini P, Attanasio G, de Vincentiis M, Lambiase A. Behçet's disease: New insights into pathophysiology, clinical features and treatment options. Autoimmun Rev. 2018 Jun;17(6):567-575.

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