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Azathioprine in multiple sclerosis

Authoring team

Azathioptine therapy in multiple sclerosis:

  • azathioprine therapy in multiple sclerosis may have similar efficacy to beta-interferon but initial trial evidence seemed less conclusive (1,2)

  • however a meta-analysis concluded that azathioprine probably does attenuate relapsing remitting MS (3)

Reference:

  • 1) Yudkin PL, Ellison GW, Ghezzi A, Goodkin DE, Hughes RA, McPherson K, Mertin J, Milanese C. Overview of azathioprine treatment in multiple sclerosis. Lancet 1991 Oct 26;338(8774):1051-5
  • 2) Palace J, Rothwell P. New treatments and azathioprine in multiple sclerosis.Lancet 1997 Jul 26;350(9073):261.
  • 3) Casetta I, Iuliano G, Filippini G. Azathioprine for multiple sclerosis. Cochrane Database Syst Rev 2007:CD003982.

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