Hyperlipidaemia secondary to cholestasis

In prolonged cholestasis features include:

• increased serum cholesterol
• may be a moderate increase in triglyceride
• serum is not lipaemic
• reduced levels of high-density lipoprotein
• persistence of remnant-like particles
• clinical features may include:
  • palmar xanthomas; tuberous xanthomas (particularly on extensor surfaces)
  • xanthomas usually only occur if cholestasis has persisted for more than 3 months
  • sometimes fat deposits may involve bone and peripheral nerves