You can view 5 more pages before signing in

High intensity versus intermediate intensity versus low intensity statin treatment (statins)

Last reviewed Aug 20, 2022

Dose of particular statin versus reduction in LDL cholesterol

Dose (mg/day)	5	10	20	40	80
fluvastatin	-	-	21% a	27% a	33% b
pravastatin	-	20% a	24% a	29% a	-
simvastatin	-	27% a	32% b	37% b	42% c,d
atorvastatin	-	37% b	43% c	49% c	55% c
rosuvastatin	38% b	43% c	48% c	53% c	-

a 20%- 30%: low intensity
b 31%- 40%: medium intensity
c Above 40%: high intensity
d Advice from the MHRA: there is an increased risk of myopathy associated with high-dose (80 mg) simvastatin. The 80 mg dose should be considered only in patients with severe hypercholesterolaemia and high risk of cardiovascular complications who have not achieved their treatment goals on lower doses, when the benefits are expected to outweigh the potential risks.

Reference:

NICE (July 2014). Lipid modification: cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease

Primary prevention of coronary heart disease

Create an account to add page annotations

Create a free account

Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.

High intensity versus intermediate intensity versus low intensity statin treatment (statins)

Related pages

Create an account to add page annotations