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Flecainide

Authoring team

Flecainide is a class IC antiarrhythmic drug.

Flecainide should be used cautiously because:

  • it is moderately negatively inotropic
  • it is arrhythmogenic
  • it increases mortality post-MI

The summary of product characteristics must be consulted before using this drug.

Notes:

  • SCN5A gene polymorphism histidine-558-to-arginine (H558R) is more prevalent in patients with atrial fibrillation (AF) compared with the general population and its presence is associated with a more favourable response to flecainide treatment (1)

Reference:

  • Trincado Ave M, Brion M, Blanco-Verea A, et al.Prevalence and relevance of H558R in the efficacy and toxicity of flecainide in patients with atrial fibrillation: a cohort study.Heart Published Online First: 01 November 2024.

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