variation in apo CIII and lipoprotein lipase genes, and reduced activity of lipoprotein lipase, are implicated in hypertriglyceridaemia and combined lipidaemia.
apo CIII gene is found on chromosome 11 as part of a cluster with apo A1 and apo AIV. Apo CIII inhibits lipoprotein lipase.
variants of apo CIII and lipoprotein lipase predispose to a defective clearance of triglyceride-rich lipoproteins, and so mean there is potential to develop hypertriglyceridaemia or combine hyperlipidaemia.
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