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Dapagliflozin - NICE guidance for treating chronic heart failure with reduced ejection fraction

Authoring team

Dapagliflozin is recommended as an option for treating symptomatic chronic heart failure with reduced ejection fraction in adults, only if it is used as an add-on to optimised standard care with:

  • angiotensin-converting enzyme (ACE) inhibitors or angiotensin-2 receptor blockers (ARBs), with beta blockers, and, if tolerated, mineralocorticoid receptor antagonists (MRAs), or
  • sacubitril valsartan, with beta blockers, and, if tolerated, MRAs

Start treatment of symptomatic heart failure with reduced ejection fraction with dapagliflozin on the advice of a heart failure specialist. Monitoring should be done by the most appropriate healthcare professional.

Reference:

  1. NICE. Dapagliflozin for treating chronic heart failure with reduced ejection fraction. Technology appraisal guidance TA679. Published February 2021

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