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Isoniazid

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

The prime indication for its use is in tuberculosis.

Caution should be exercised when using it in the presence of:

  • epilepsy
  • history of psychosis
  • alcoholism
  • impaired liver and kidney function
  • breast feeding

Contra-indications include:

  • drug-induced liver disease
  • porphyria

Side-effects of isoniazid include:

  • peripheral neuropathy with high doses or in patients with pyridoxine deficiency
  • convulsions
  • psychotic episodes
  • nausea and vomiting
  • hypersensitivity reactions including rashes
  • agranulocytosis
  • hepatitis
  • SLE like syndrome

Routes of administration:

  • oral:
    • tablets
    • elixir
  • i.m. injection
  • i.v. injection

The summary of product characteristics should be consulted before prescribing this drug.

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