Prevention of the coagulation cascade promoting a thrombus throughout the circulation resides with a number of physiological systems:
In practice, the systems interact in a dynamic manner towards a final common pathway of fibrin dissolution.
If required, non-physiological stimulation - with anticoagulants and thrombolytics - and inhibition - e.g. with tranexamic acid, aprotinin, desmopressin and ethmasylate - can modulate the system.
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