Etoposide is a cytotoxic agent and is a derivative, like teniposide, of the mandrake plant, and is a semi-synthetic glycoside derivative of podophyllotoxin.
These drugs, like the vinca alkaloids, bind to tubulin. However their action is probably related to effects on topoisomerase II, blocking DNA synthesis.
The dose-limiting toxicity with etoposide is myelosuppression, with a nadir of 12 to 25 days after treatment.
Annotations allow you to add information to this page that would be handy to have on hand during a consultation. E.g. a website or number. This information will always show when you visit this page.