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Cranial irradiation

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Cranial irradiation is used in high dose for intracranial malignancy alone, or in conjunction with surgery and chemotherapy.

It is effective in treating sanctuary sites of leukaemia in the brain.

Side effects include:

  • reduced IQ - degradation of short term memory, arithmetic and attention
  • hypothalamic pituitary damage - including hypothyroidism, growth hormone deficiency and precocious puberty

These adverse effects are worse:

  • with higher doses and increased frequency of therapy
  • with young children

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