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Unstable trinucleotide repeats

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Dynamic mutations, notably the expansion of trinucleotide repeats within the genome, have been associated with a number of clinical disorders which can be subdivided into:

  • neurodegenerative diseases, such as Huntington's disease
  • mental retardation, such as fragile X syndrome

Myotonic dystrophy is caused by dynamic mutations but cannot be easily assigned to either group.


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