adrenaline is an endogenous catecholamine with potent alpha, beta 1, and beta 2 adrenergic actions
adrenaline induces vasoconstriction, increases coronary perfusion pressure, enhances the contractile state of the heart, stimulates spontaneous contractions, and increases the intensity of VF so increasing the likelihood of successful defibrillation
recommended IV/IO dose of adrenaline in children is 10 microgram per kg
dose of adrenaline via the tracheal tube route is ten times the IV dose (100 microgram per kg)
this route should be avoided if at all possible as evidence shows that there may be a paradoxical effect
subsequent doses of adrenaline, if needed, should be given every 3-5 min
Reference:
Resuscitation Council (UK). Advanced Paediatric Life Support. Guidelines 2005.
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