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Regulation

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Bile salt production is regulated by the concentration of bile salts circulating within plasma. There is a negative feedback loop upon 2 target enzymes:

  • HMG CoA reductase, the enzyme which produces cholesterol within hepatocytes
  • 7-alpha-hydroxylase, the enzyme involved in making the precursor or primary bile acids

Consequently, an elevated plasma bile salt concentration decreases primary bile salt production, and vice versa.

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