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Drugs such as hydralazine may be associated with the development of an SLE-like syndrome.
However, compared to idiopathic SLE, in drug-induced SLE:
People with the HLA-DR3 antigen seem particularly at risk of developing a drug-induced SLE. Such patients are "slow acetylators" - they have a genetically determined inability to acetylate the amine or hydralazine moiety of these drugs.
Nonacetylated metabolites accumulate, bind to nucleoprotein or cellular macromolecules, form an antigenic complex and induce an autoimmune reaction.
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