Often large Peyer's patches are noted at surgery, leading to the suggestion that there may be an infective aetiology for this condition. Adenovirus has been suggested. The enlarged Peyer's patches create an axis on which the process of invagination can occur.
Polyps and a Meckel's diverticulum may also predispose this condition in a similar way to enlarged Peyer's patches.
Intussusception may also occur in Henoch-Schonlein purpura.
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